eural stress processing and risk of coronary heart disease

Not Applicable

• Conditions: stress; I25; Chronic ischaemic heart disease

• Registration Number: DRKS00005362
• Lead Sponsor: Zentralinstitut für Seelische Gesundheit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10-15
• Study Completion: 2016-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

written informed consent

Exclusion Criteria

1. evidence of overt CHD 2. active or uncontrolled physical or mental disorders 3. use of betablockers or steroids 4. disorders or issues prohibiting MRT

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Increase in subjective stress level, measured by visual analogue scale immediately before and after stress exposure.

Secondary Outcome Measures

Name	Time	Method
1. Increase of saliva cortisol concentration associated with mental stress exposure, measured by immunoassay immediately before and 30 minutes after stress exposure<br>2. Experimental versus control contrast in pACC activity associated with mental stress exposure, measured by fMRI, as compeared to a control condition (cognitive challenge without stress exposure). The stress paradigm uses a block design with repeated 60 seconds task (or control) blocks that are preceded by 5 seconds instruction phase and followed by 20 seconds pause.