Cardiac ischemia due to physical or mental stress in women with suspected coronary microvascular dysfunction (CMD)
Completed
- Conditions
- coronary microvascular dysfunctionCoronary microvascular dysfunction (microvascular angina pectoris)
- Registration Number
- NL-OMON42965
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
- Women 40-65 years, with a clinical diagnosis of CMD; based on symptoms and/or signs of ischemia, the presence of multiple CV risk factors and absence of obstructive coronary artery disease
- CMD with symptoms of ischemia at least twice a week
Exclusion Criteria
- Symptoms of ischemia due to obstructive CAD
- An altered diurnal rhythm, such as by working night shifts or insomnia.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Occurrence of cardiac ischemia (defined as >= 1.5 mm ST segment depression in >=3<br /><br>consecutive cardiac cycles) in the 24 hours following a mental or physical<br /><br>stress test. </p><br>
- Secondary Outcome Measures
Name Time Method <p>- Relation between stress test and cortisol and hs CRP levels<br /><br>- Time between stress test and occurrence of ischemia</p><br>