Effect of systemic melatonin in periodontal therapy

Phase 4

Not yet recruiting

• Conditions: Other specified diseases of jaws,

• Registration Number: CTRI/2022/12/048262
• Lead Sponsor: Other self

Brief Summary

Melatonin is secreted by the pineal gland in circadian cycles, mainly during sleep. However, a small portion is also produced by the salivary glands. Therefore, we chose melatonin to test if it might contribute to the prevention of severe oral inflammation and improve the bone regeneration compared to patients without melatonin supplementation.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-12-16
• Study Start: 2022-12-25

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• 1.systemically healthy Subjects with periodontal disease indicated for flap surgery 2.
• Subjects with three/two walled intrabony defects that can be regenerated.

Exclusion Criteria

• Subjects without periodontal disease 2.
• Subjects with periodontal disease not requiring regenerative therapy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Level of alkaline phosphatase and bone sialoprotein at baseline and 4 weeks after intervention	at baseline and 4 weeks after intervention

Secondary Outcome Measures

Name	Time	Method
Clinical parameters: probing depth, clinical attachment loss	Base line, 3 months
Levels of melatonin	Baseline, 1 month

Trial Locations

Locations (1)

Saveetha Dental College and Hospitals; 🇮🇳 Thiruvallur, TAMIL NADU, India

Saveetha Dental College and Hospitals

🇮🇳Thiruvallur, TAMIL NADU, India

Iram Rafique Pawane

Principal investigator

9619245546

iramrafique2396@gmail.com