Normal Brain Imaging Database for Brain Disorder Studies

Not Applicable

Active, not recruiting

• Conditions: Healthy
• Interventions: Device: transcranial direct current stimulation

• Registration Number: NCT03027869
• Lead Sponsor: University of Manitoba

Brief Summary

Healthy volunteers will be recruited. All subjects will be tested a battery of neuropsychological tests, then undergo fluorodeoxyglucose-positron emission tomography (PET) and magnetic resonance imaging (MRI). During the PET and MRI, they will be stimulated with transcranial direct current stimulation (tDCS) for 15 minutes. A third of subjects will receive real tDCS on the left prefrontal cortex, a third on the right prefrontal cortex, and the other third will receive sham tDCS.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-01-16
• Study First Submitted QC: 2017-01-18
• Study First Posted: 2017-01-23
• Study Start: 2017-06-28
• Primary Completion: 2020-03-11
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-28
• Last Update Posted: 2025-04-03
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• N/A

Exclusion Criteria

• History of any neurological or psychiatric diseases;
• Abnormal MRI;
• metal implants or a cardiac pacemaker;
• Pregnant or breastfeeding women (female subjects of child bearing potential will be screened for pregnancy before MRI imaging).
• severe hypertension.
• cardiovascular disease.
• Family history of epilepsy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Real Left DLPFC tDCS	transcranial direct current stimulation	Real tDCS on the left dorsolateral prefrontal cortex
Sham tDCS	transcranial direct current stimulation	30sec ramp-up and 30sec ramp-down
Real Right DLPFC tDCS	transcranial direct current stimulation	Real tDCS on the right dorsolateral prefrontal cortex

Primary Outcome Measures

Name	Time	Method
functional connectivity	immediate (less than 30 minutes)	The functional connectivity of the right caudate nucleus will be estimated using graph theory analysis technique of resting-state fMRI.

Secondary Outcome Measures

Name	Time	Method
Stroop task performance	immediate (less than 60 minutes)	the executive function that is thought to involve the caudate nucleus will be examined

Trial Locations

Locations (1)

University of Manitoba; 🇨🇦 Winnipeg, Manitoba, Canada