EFFECT OF VITAMIN D REPLACEMENT ASSOCIATED WITH ADAPTIVE IMMUNE RESPONSE IN CHRONIC HEPATITIS C PATIENTS WITH VITAMIN D DEFICIENCY

Not Applicable

Completed

• Conditions: Vitamin D deficiencyChronic Hepatitis C T- Helper1/2 cytokinesIP- 10 levelDPP4 level; C06.552.380.350.120

• Registration Number: TCTR20160429001
• Lead Sponsor: o

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2014-12-31
• Study Start: 2016-04-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1.Thai male or female, aged 18-70 years old.
2.Chronic hepatitis C which was diagnosed more than 6 months.
-Albumin > 3.4 mg/dl - Total bilirubin < 1.5 mg/dl
-INR < 1.5 - Platelet > 75,000
3.Compensated liver cirrhosis.
4.Consent for participation.
5.Serum 25 OH vitamin D level < 30 ng/ml.

Exclusion Criteria

1.Underlying disease(s) ; Human Immunodeficiency virus (HIV) infection, autoimmune disease.
2.Decompensated Liver Cirrhosis.
3.Pregnancy and/or lactating women.
4.Active viral or bacterial infection.
5.History of steroids or immunosuppressive therapy
6.No history of Pegylated interferons and interferons based therapies, interferons withdrawal at least 6 months, ingestion of drugs potentially capable of interacting with immune system

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
T-Helper1/2 cytokines levels 6 weeks Cytokine quantitation was performed on bead-based ELISA

Secondary Outcome Measures

Name	Time	Method
IP-10,DPP-4 levels 6 weeks quantitative sandwich enzyme immunoassay technique