Relationship between Mitochondrial DNA Damage and Atherosclerosis
Not Applicable
- Conditions
- Healthy volunteer, patietns with hypertension, dyslipidemia, diabetes, chronic kidney disease, peripheral artery disease, coronary heart disease, cerebrovascular disease, or heart failure, and current smoker.
- Registration Number
- JPRN-UMIN000019872
- Lead Sponsor
- Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University
- Brief Summary
We enrolled 175 subjects. We assessed the associations of mtDNA with traditional risk factors and flow-mediated vasodilation. However, there was no significant associations between them, indicating that mtDNA may not be useful as a marker of atherosclerosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 175
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who are considered not eligible for the study by the attending doctor.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method (1)The association between mtDNA damage level and conventional cardiovascular risk factors. (2) The association between mtDNA damage level and endothelial function.
- Secondary Outcome Measures
Name Time Method