Evaluation of carcinogenicity of chlorhexidine mouthwash on oral mucosa
Phase 2
Recruiting
- Conditions
- Carcinogenic effect of chlorhexidine mouthwash.
- Registration Number
- IRCT20180714040460N7
- Lead Sponsor
- Islamic Azad University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Be in the treatment of phase one gingivitis
be between 20-30 years old
Have gingivitis
Exclusion Criteria
The smoking group includes samples with a history of consumption of more than 5 years and above 20 cigarettes per day that are considered Heavy Smoker
criteria for taking certain drugs (such as antiretrovirals, doses containing statins, ..)
Drug addiction
engaging in high-risk occupations such as the paint industry, etc
recent viral illness
Undergoing radiotherapy or Less than one year history for radiotherapy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Micronucleus. Timepoint: Before scaling and one week after using chlorhexidine mouthwash. Method of measurement: Cell count with light microscope with 400 magnification.;Karyorrehxis. Timepoint: Before scaling and one week after using chlorhexidine mouthwash. Method of measurement: count with light microscope with 400 magnification.;Karyolysis. Timepoint: Before scaling and one week after using chlorhexidine mouthwash. Method of measurement: count with light microscope with 400 magnification.;Broken egg. Timepoint: Before scaling and one week after using chlorhexidine mouthwash. Method of measurement: count with light microscope with 400 magnification.;Repair index. Timepoint: It is calculated after counting nuclear changes. Method of measurement: Mean karyolysis and karyorexia divided by the mean of micronucleus and Broken ag.
- Secondary Outcome Measures
Name Time Method