Analysis of in Vitro Biological Reaction of Diaphragmatic Prothesis When Congenital Diaphragmatic Hernia (CDH) Repair
- Conditions
- Congenital Diaphragmatic Repair
- Registration Number
- NCT03316924
- Lead Sponsor
- University Hospital, Strasbourg, France
- Brief Summary
In case of CDH, the incomplete development of a part of the diaphragm allows abdominal viscera to herniate into thorax cavity during fetal development and impaired lung and heart development.
After birth, CDH patients who survived thanks to an active reanimation management undergo diaphragmatic repair. In case of large defect, a patch is needed to complete diaphragmatic closure. Thanks to primary cell culture from foreskin, peritoneal epithelium or cremaster dedicated to incineration investigators want to analyse biological integration of actually used prothesis and others innovations.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1
- Minor aged 0 (day of birth) to 14 years
- Patient for whom an indication of posthectomy and / or cure of inguinal hernia and / or testicular ectopy is retained
- Patient whose legal representatives have agreed to the use of operational waste from mesenchymal tissues (foreskin, cremaster and peritoneum) destined for incineration.
- Patient affiliated to a social security scheme
- parents don't agree to the use of its operating waste for research purposes
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method cell colonization samples are processed immediately after sampling Study cell colonization
quality of the extracellular matrix samples are processed immediately after sampling Quality of the extracellular matrix produced in vitro in contact with the currently used implant materials compared to biomaterials under development
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Les Hôpitaux Universitaires de Strasbourg
🇫🇷Strasbourg, France