Identification of Biomarkers for Post-COVID Conditions
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 208
- 试验地点
- 1
- 主要终点
- Dyspnea
研究概览
简要总结
The COVID-19 infection affects humans differently. While some recover quickly and fully, others develop serious illnesses and late complications. The term late complications describe symptoms that last for 12 weeks or longer after COVID-19 infection is detected. The aim of the present project is to investigate whether it is possible to identify genetic factors that occur more frequently in people suffering from COVID-19 late complications than in those who do not develop late complications. The investigators aim to develop a genetic profile that identifies individuals at high risk for late complications of COVID-19. Number and nature of late complications will be analysed to identify patterns in the incidence of late complications associated with certain genetic traits. The study is designed as a case-control study and is expected to include 500 subjects between 18 and 65 years of age who at least 12 weeks ago tested positive for COVID-19; 250 who suffer from late complications and 250 who have fully recovered.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 to 65 years
- •SARS-CoV-2 infection proven by a PCR test at least 12 weeks prior to inclusion
- •Only cases: Referred to the Clinic of post-COVID conditions located in Region Zealand, Denmark
排除标准
- •Need of being on a respirator during infection with SARS-CoV-2
- •Only controls: complain about long covid 12 weeks or more after proven infection with SARS-CoV-2
结局指标
主要结局
Dyspnea
时间窗: At inclusion
Measured by means of Medical Research Council Dyspnoea Scale (MRC), which is a single-item, rated on a 5-point likert-scale in the range 1 to 5, with higher scores indicating worse symptoms.
次要结局
- Ability to cope(At inclusion)
- Hand grip strength (HGS)(At inclusion)
- Psychic stress(At inclusion)
- Cognitive impairment(At inclusion)
- Level of Personality Functioning(At inclusion)
- Physical and mental health(At inclusion)
- Work Rehabilitation(At inclusion)
- Sexual function assessed by Female Sexel Function Index (FSFI_R)(At inclusion)
- Sexual function(At inclusion)