Zinc and DNA Health

Not Applicable

• Conditions: ow Zinc status in elderly population; Low Zinc status in elderly population; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12610000059066
• Lead Sponsor: Commonwealth Scientific Industrial Research Organization

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-01-19
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Healthy men and women aged over 65 years

Exclusion Criteria

Individuals supplementing with more than 25% of the recommended dietary intake of zinc. Individuals with habitual dietary intake > 20 mg/day. Individuals undergoing radiotherapy/chemotherapy treatment for cancer. Individuals with plasma zinc > 10.5 micromoles

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood collected will be isolated for lymphocytes to provide a means of measurement for genetic damage. Deoxyribonucleic Acid (DNA) damage in lymphocytes can be assessed using Cytokinesis Block Micronucleus Cytome (CBMN-Cyt) assay which is a reliable and comprehensive method to evaluate DNA damage, cytostasis and cytotoxicity events in lymphocytes.[Day 0 baseline and day 90,end of intervention]

Secondary Outcome Measures

Name	Time	Method
We will utilize buccal cells as a non-invasive method to measure DNA damage by performing Buccal Micronucleus Cytome (BM-Cyt) assay. Buccal cells collected from consented participants will be used to prepare microscope slides to investigate genomic instability, cell proliferation and cell death parameters as previously described.[Day 0 baseline and day 90, end of intervention]