NCT02982356
Unknown
Not Applicable
Prenatal Screening, Diagnosis and Intrauterine Intervention of Fetal Abnormal Chromosome and Structure in Twins Pregnancy
DrugsPotassium Chloride
Overview
- Phase
- Not Applicable
- Intervention
- Fetal Selective Reduction Technology
- Conditions
- Chromosome Abnormality
- Sponsor
- Shanghai First Maternity and Infant Hospital
- Enrollment
- 1300
- Primary Endpoint
- Success rate for the operation
- Last Updated
- 9 years ago
Overview
Brief Summary
The risk of abnormal chromosome and structure is much higher in twins than in singletons, and traditional early pregnancy screening strategy for single pregnancy is not suitable for twins. Based on our management experience of fetal medicine at twin pregnancy, and multi-center cooperation, the study will carry out the following clinical studies:
- to explore a suitable, early, noninvasive and accurate prenatal screening strategy for twin pregnancy.
- fetal chromosomal abnormalities
Investigators
Eligibility Criteria
Inclusion Criteria
- •ultrasound diagnosis as twin pregnancy
- •at 11-14 gestational weeks
Exclusion Criteria
- •Multiple pregnancies (three or more)
- •Maternal history of chromosome aneuploidy abnormality or tumor
Arms & Interventions
Fetal Selective Reduction Technology
Potassium chloride fetal heart injection in the dichorial twins with abnormal chromosome and structure
Intervention: Fetal Selective Reduction Technology
Fetal Selective Reduction Technology
Potassium chloride fetal heart injection in the dichorial twins with abnormal chromosome and structure
Intervention: Potassium Chloride
Outcomes
Primary Outcomes
Success rate for the operation
Time Frame: 1 week
Secondary Outcomes
- long-term complications after surgery(1 year)
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