Prenatal Screening, Diagnosis and Intrauterine Intervention of Fetal Abnormal Chromosome and Structure in Twins Pregnancy
Not Applicable
- Conditions
- Chromosome AbnormalityTwin Pregnancy With Antenatal Problem
- Interventions
- Procedure: Fetal Selective Reduction TechnologyDrug: Potassium Chloride
- Registration Number
- NCT02982356
- Lead Sponsor
- Shanghai First Maternity and Infant Hospital
- Brief Summary
The risk of abnormal chromosome and structure is much higher in twins than in singletons, and traditional early pregnancy screening strategy for single pregnancy is not suitable for twins. Based on our management experience of fetal medicine at twin pregnancy, and multi-center cooperation, the study will carry out the following clinical studies:
1. to explore a suitable, early, noninvasive and accurate prenatal screening strategy for twin pregnancy.
2. fetal chromosomal abnormalities
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 1300
Inclusion Criteria
- ultrasound diagnosis as twin pregnancy
- at 11-14 gestational weeks
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Exclusion Criteria
- Multiple pregnancies (three or more)
- Maternal history of chromosome aneuploidy abnormality or tumor
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Fetal Selective Reduction Technology Fetal Selective Reduction Technology Potassium chloride fetal heart injection in the dichorial twins with abnormal chromosome and structure Fetal Selective Reduction Technology Potassium Chloride Potassium chloride fetal heart injection in the dichorial twins with abnormal chromosome and structure
- Primary Outcome Measures
Name Time Method Success rate for the operation 1 week
- Secondary Outcome Measures
Name Time Method long-term complications after surgery 1 year