Biological Evolution of Whipple's Disease (WHIP)

Completed

• Conditions: Whipple Disease

• Registration Number: NCT06776484
• Lead Sponsor: University Hospital, Brest

Brief Summary

Whipple's disease (WD), a rare systemic infection by Tropheryma whipplei, lacks research on biological abnormalities pre- and post-treatment. This study explores these abnormalities for their diagnostic and monitoring value.

Detailed Description

Whipple's disease (WD) is a rare systemic infection caused by \*Tropheryma whipplei\*. Despite advancements in diagnosis through PCR and biopsy, there is limited research comparing biological abnormalities before and after treatment. This study aimed to characterize these abnormalities and evaluate their potential for aiding in diagnosis and monitoring.

Study Timeline

• Study Start: 2024-09-01
• Status Verified: 2024-12
• Study First Submitted: 2024-12-18
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31
• Study First Submitted QC: 2025-01-14
• Last Update Submitted: 2025-01-14
• Study First Posted: 2025-01-15
• Last Update Posted: 2025-01-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients with at least one positive PCR test for Whipple's disease and a retained diagnosis at Brest University Hospital between 2010 and 2024
• Major patient

Exclusion Criteria

• Minors
• No screening test for Whipple's disease
• Opposition to participation
• Protected patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Biological changes	1 day	Biological changes (inflammation, liver function tests, haematology, lymphocyte subpopulations) in patients diagnosed with classic, localised or reactive Whipple's disease

Trial Locations

Locations (1)

Chu Brest; 🇫🇷 Brest, France