The effects of low dose 1,25-dihydroxyvitamin D3 on the polarising of cellular immune reactivity towards type two immunity

Completed

• Conditions: Auto-immune diseases; Haematological Disorders; Immune disorders

• Registration Number: ISRCTN12365646
• Lead Sponsor: VU University Medical Center (The Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-12-28
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 24

Inclusion Criteria

1. Written informed consent
2. Women, aged 20 to 30 years
3. Use of oral contraception with estrogen and progestin
4. Apparently healthy

Exclusion Criteria

1. Men
2. Pregnancy
3. Smoking
4. Alcohol abuse: more than 3 Units/day
5. Use of drugs, except for incidental analgesic agents
6. Use of diuretic medication or corticosteroids
7. Auto immune diseases
8. Renal impairment (serum creatinine more than 150 µmol/l)
9. Malignant disease
10. Kidney-stones (also when this occurs in the family), urinary tract infections
11. Infectious diseases
12. Use of antibiotics
13. Use of any medication that influence T-lymphocytes or vitamin D metabolism
14. Disease or use of any medication known to affect Ca metabolism or skeletal physiology
15. Serious mental impairment i.e. preventing to understand the study protocol/aim

Study & Design

• Study Type: Interventional
• Study Design: Not specified