Effect of 1,25-dihydroxyvitamin D3 (calcitriol) on mortality of in-hospital sepsis/septic shock patients
Phase 2
- Conditions
- sepsis septic shock
- Registration Number
- TCTR20161101004
- Lead Sponsor
- Faculty of Medicine Siriraj Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Patient age >/= 18 years old and
Severe sepsis/ septic shock (Hospital acquired infection) and
Admitted in hospital more than 48 hours
Exclusion Criteria
Hypercalcemia (serum calcium >/= 10 mg/dl)
Hyperphosphatemia (serum phosphate >/= 6 mg/dl)
Current therapy with nutritional vitamin D at any doses
History of primary parathyroid disease
Metabolic bone disease
Expected to die within 48 hours
Pregnancy
History of transplantation
Malignancy with poor prognosis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method mortality rate 28 days mortality
- Secondary Outcome Measures
Name Time Method Organ failure after drug administration new ventilator requirement, new RRT in 24, 48 hours and duration of vasopressor requirement,Severity of illness after drug administration SOFA score improvement, length of hospital stay and hospital mortality ,Vitamin D status inclusion date serum vitamin D level