Significance of Synbiotics on Inflammation and Proliferation of Colonic Mucosa
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Region Skane
- 入组人数
- 12
- 主要终点
- Reactivity of rectal mucosa
研究概览
简要总结
There is a constant exchange between the gut epithelium and lumen, including microbial interplay. The aim of this study was to investigate dietary test products on inflammatory proliferation markers in the gut, and thereby if the products had positive effects in the gut as well as in other parts of the body.
The hypothesis was that the test products would reduce the inflammatory and proliferation activity of the gut epithelium by fermentation of normal food products and by converting dietary phenolic compounds into anti-inflammatory substances.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-80 years old,
- •Able to understand oral and written information,
- •Informed consent
排除标准
- •Ongoing immune suppressive treatment, incl. cortisone,
- •Ongoing antibiotic treatment or antibiotic treatment ended within 4 weeks,
- •History of inflammatory bowel disease
研究组 & 干预措施
Probiotics_Bifidobacterium
Intervention (2 weeks) of daily supplementation of a probiotic strain of Bifidobacterium.
干预措施: Bifidobacterium (Dietary Supplement)
Probiotics_Lactobacillus
Intervention (2 weeks) with a strain of Lactobacillus
干预措施: Lactobacillus (Dietary Supplement)
结局指标
主要结局
Reactivity of rectal mucosa
时间窗: after 2 weeks intervention
to study the reactivity of rectal mucosa after a standardized inflammatory insult before and after treatment with probiotics
次要结局
- influence on immune system(after 2 weeks intervention)