Investigating the link between taste perception and circulating levels of of insulin (and related metabolic hormones): a pilot study.

Completed

Conditions: taste and hormonal regulation
Taste-induced regulation of metabolic hormones
10018424
10003018

Registration Number: NL-OMON36154

Lead Sponsor: Onze Lieve Vrouwe Gasthuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Healthy subjects: male, caucasian, age 30-55, Body Mass Index between 18.5 and 24.9, that are tasters (n=15) and non-tasters (n = 15)
male diabetic subjects type 2 age 30-55, bmi> 18.5 (n=10)

Exclusion Criteria

Healthy subjects : Age below 30 years or over 55 years, Body mass index lower than 18.5 kg/m2 or higher than 24.9 kg/m2, Psychiatric morbidity (eating disorder, depression, alcoholism), Co-morbidity, (cardiovascular disease, thyroid disease, diabetes), Previous history of cancer, Use of regular anti-inflammatory medication, Consumption of diets or supplements high in phytoestrogens, Smoking
Diabetics: use of GLP-1 agonists; BMI < 18,5, other exclusion criteria as healthy subjects

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Fasting plasma and saliva levels of circulating hormones (Ghrelin, Leptin,<br /><br>Insulin, GIP, GLP-1, PP, PYY, BDNF, NPY, Adiponectin)<br /><br>- Picture of the tongue to count the number of taste buds per cm2<br /><br>- Taste perception assessment with PTC strips<br /><br>- A copy of the handpalm and fingers of the right hand, which will enable the<br /><br>analysis of the potential influence of prenatal hormones by calculating the<br /><br>ratio between the index and the ring finger</p><br>

Secondary Outcome Measures