Chronic dietary modification versus supplementation with glycine betaine, on fasting and post-methionine load homocysteine concentrations in healthy volunteers.

Phase 3

• Conditions: Healthy volunteers; Diet and Nutrition -

• Registration Number: ACTRN12606000104550
• Lead Sponsor: Canterbury Health Laboratories

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-03-20
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

Healthy volunteers with no previous history of vascular disease and no illness requiring medication, normal homocysteine concentration.

Exclusion Criteria

The presence of vitamin B12, vitamin B6 or folate deficiency, and/or 677->T polymorphisms in the methylene reductase gene.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Homocysteine concentrations[At 1, 3, 7, 10, 14, 16 and 20 days post-treatment]

Secondary Outcome Measures

Name	Time	Method
Plasma glycine betaine, choline, methionine, and urine glycine betaine and choline concentrations.[At 1, 3, 7, 10, 14, 16 and 20 days post-treatment. ];For each treatment period, duplicate food samples will be also be assayed for glycine betaine and choline measurement to confirm the amount ingested.[]