The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung Compliance

Not Applicable

• Conditions: Sepsis; ARDS; Traumatic Brain Injury

• Registration Number: NCT03341572
• Lead Sponsor: Jingyuan,Xu

Brief Summary

To observe the effect of PEEP on CVP among patients with different respiratory compliance

Detailed Description

30 patients with mechanical ventilation and inserted central venous line will be entered. After gathering demographic data, patients undergone 5,10 and 15cmH2O PEEPs and the respective CVPs of the mentioned points will be recorded. According to the change of CVP, the patients will be divided into high response group and low response group, then comparing the lung compliance and thorax elastic resistance differences between the two groups.

Study Timeline

• Status Verified: 2017-11
• Study First Submitted: 2017-11-08
• Study Start: 2017-11-13
• Study First Submitted QC: 2017-11-13
• Last Update Submitted: 2017-11-13
• Study First Posted: 2017-11-14
• Last Update Posted: 2017-11-14
• Primary Completion: 2017-12-30
• Study Completion: 2017-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Patients with mechanical ventilation and inserted central venous line

Exclusion Criteria

1. The age is less than 18 years old or more than 80 years old；
2. Pregnant and lying-in woman；
3. Patients undergoing fluid resuscitation and the speed is more than 200ml/h；
4. Patients with norepinephrine dose are greater than 15 micro per minute；
5. Patients with pericarditis、pulmonary heart disease、right heart failure、atrial fibrillation；
6. Patients with COPD(endogenous PEEP is more than 2cmH2O)、tension pneumonthorax、acute episode asthma

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
CVP	half an hour	Measure the central venous pressure of the three level PEEPs of 5,10 and 15cmH2O.

Trial Locations

Locations (1)

Zhongda Hospital; 🇨🇳 Nanjing, Jiangsu, China