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Clinical Trials/NCT03341572
NCT03341572
Unknown
Not Applicable

The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung Compliance

Jingyuan,Xu1 site in 1 country30 target enrollmentNovember 13, 2017
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ConditionsSepsisARDSTraumatic Brain Injury

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Sepsis
Sponsor
Jingyuan,Xu
Enrollment
30
Locations
1
Primary Endpoint
CVP
Last Updated
8 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

To observe the effect of PEEP on CVP among patients with different respiratory compliance

Detailed Description

30 patients with mechanical ventilation and inserted central venous line will be entered. After gathering demographic data, patients undergone 5,10 and 15cmH2O PEEPs and the respective CVPs of the mentioned points will be recorded. According to the change of CVP, the patients will be divided into high response group and low response group, then comparing the lung compliance and thorax elastic resistance differences between the two groups.

Registry
clinicaltrials.gov
Start Date
November 13, 2017
End Date
December 30, 2017
Last Updated
8 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Jingyuan,Xu
Responsible Party
Sponsor Investigator
Principal Investigator

Jingyuan,Xu

Attending doctor

Southeast University, China

Eligibility Criteria

Inclusion Criteria

  • •Patients with mechanical ventilation and inserted central venous line

Exclusion Criteria

  • •The age is less than 18 years old or more than 80 years old；
  • •Pregnant and lying-in woman；
  • •Patients undergoing fluid resuscitation and the speed is more than 200ml/h；
  • •Patients with norepinephrine dose are greater than 15 micro per minute；
  • •Patients with pericarditis、pulmonary heart disease、right heart failure、atrial fibrillation；
  • •Patients with COPD(endogenous PEEP is more than 2cmH2O)、tension pneumonthorax、acute episode asthma

Outcomes

Primary Outcomes

CVP

Time Frame: half an hour

Measure the central venous pressure of the three level PEEPs of 5,10 and 15cmH2O.

Study Sites (1)

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