Combination of NMDA-enhancing and Anti-inflammatory Treatments for Ultra-resistant Schizophrenia
- Conditions
- Schizophrenia
- Registration Number
- NCT05240976
- Lead Sponsor
- China Medical University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria:<br><br> - Have a DSM-5 (American Psychiatric Association) diagnosis of schizophrenia<br><br> - Are treatment-resistant to standard treatments of at least two specific<br> antipsychotics before clozapine treatment<br><br> - Are receiving adequate trials of clozapine for more than 12 weeks but without<br> satisfactory response<br><br> - PANSS total score = 70; SANS total score = 40<br><br> - Have sufficient education to communicate effectively and are capable of completing<br> the assessments of the study<br><br> - Agree to participate in the study and provide informed consent<br><br>Exclusion Criteria:<br><br> - DSM-5 diagnosis of intellectual disability or substance (including alcohol) use<br> disorder<br><br> - History of epilepsy, head trauma, or serious medical or central nervous system<br> diseases (other than schizophrenia) which may interfere with the study<br><br> - Clinically significant laboratory screening tests (including blood routine,<br> biochemical tests)<br><br> - Pregnancy or lactation<br><br> - Inability to follow protocol
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change of cognitive function
- Secondary Outcome Measures
Name Time Method Change of Positive and Negative Syndrome Scale (PANSS);Change of scale for the Assessment of Negative Symptoms (SANS) total score;Chang of positive subscale of PANSS;Change of negative subscale of PANSS;Change of general Psychopathology subscale of PANSS;Change of clinical Global Impression;Change of global Assessment of Functioning;Change of hamilton Rating Scale for Depression;Change of quality of Life Scale