Effect of NSAIDs in H.pylori treatment
- Conditions
- Helicobacter pylori.Helicobacter pylori [H.pylori] as the cause of diseases classified
- Registration Number
- IRCT201204059256N2
- Lead Sponsor
- Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 172
Inclusion criterion: patients with H.pylori infection. Exclusion criteria: previous treatment for H. pylori infection; use of PPI (proton pomp inhibitors) during 2 weeks and/or antibiotics during 4 weeks before the study; having peptic ulcer, GERD, gastrointestinal malignancy, previous gastro-oesophageal surgery; severe concomitant cardiovascular, hypertention, respiratory or endocrine diseases, clinically significant renal or hepatic disease, haematological disorders; any other clinically significant medical conditions that could increase risk; history of allergy to any of the drug used in the study; pregnancy or lactation; alcohol abuse; drug addiction; severe neurological or psychiatric disorders and contraindication of consumption of NSAID and long-term use of corticosteroids or anti-inflammatory drugs
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Helicobacter pylori eradication. Timepoint: 4-6 weeks after completion of treatment. Method of measurement: stool antigen assay for H. pylori.
- Secondary Outcome Measures
Name Time Method Symptoms improvement. Timepoint: 8-10 weeks after treatment. Method of measurement: glasgow dyspepsia severity questionnaire.