Bronchial Allergen Provocation Tests in Asthmatics in Guangzhou
- Conditions
- Allergic Asthma
- Interventions
- Other: house dust mites
- Registration Number
- NCT02504528
- Lead Sponsor
- Guangzhou Institute of Respiratory Disease
- Brief Summary
The purpose of this study is to establish the methodology of bronchial provocation tests with house dust mites in China, and to evaluate its safety and effects on upper and lower airways inflammation.
- Detailed Description
After screening,each participant undergo baseline lung function test,airway inflammation evaluation (blood and sputum eosinophils count,interleukin-13 (IL-13),FeNO)and airway responsiveness tests(methacholine bronchial provocation,nasal histamine provocation).
On the second day,the participant undergo bronchial house dust mites challenge tests.
On the third day,the participant undergo the lung function test,airway inflammation evaluation (blood and sputum eosinophils count,IL-13,FeNO)and airway responsiveness tests(methacholine bronchial provocation,nasal histamine provocation).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- Clinical diagnosis of asthma;
- Sensitive to house dust mite;
- Stable for more than 4 weeks with FEV1≥70%pred
- exacerbation within 3 months;
- upper airway infections within 6 weeks;
- concomitant of hypertension or heart diseases;
- pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description allergic asthma house dust mites asthma patients that sensitive to house dust mites. normal controls house dust mites normal controls with or without sensitive to house dust mites.
- Primary Outcome Measures
Name Time Method percentages of the participants that tested positive to house dust mites bronchial provocation 30 minutes after house dust mites bronchial provocation
- Secondary Outcome Measures
Name Time Method percentages of the participants that tested positive to house dust mites bronchial provocation measured by impulse oscillometry 10 minutes after house dust mites bronchial provocation Changes of provocative concentration induced a 60% increase in nasal airway resistance to histamine before and after house dust mites bronchial provocation 24 hours after house dust mites bronchial challenge By Comparison with methacholine provocation test
Changes of the percentages of eosinophils in sputum, nasal lavage and fractional exhaled nitric oxide (FeNO) from baseline 30mins, 7 and 24 hours after bronchial challenge Changes of provocative concentration induced a 20% decrease in forced expiratory volume at one second (FEV1) to methacholine before and after house dust mites bronchial provocation 24 hours after house dust mites bronchial challenge
Trial Locations
- Locations (1)
Guangzhou institute of respiratory disease
🇨🇳Guangzhou, Guangdong, China