Lesion Contiguity in Very High Power-short Duration Ablation
- Conditions
- Atrial Fibrillation
- Registration Number
- NCT05368610
- Lead Sponsor
- University of Barcelona
- Brief Summary
This observational trial investigates the effect of very high power-short duration radiofrequency ablation on lesion contiguity as assessed by late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR). Patients with paroxysmal or early persistent atrial fibrillation (AF) scheduled for pulmonary vein isolation (PVI) undergo point-by-point ablation using the QDOT micro catheter applying Qmode+ (90W over 4 seconds). All patients receive an LGE-CMR 3 months after the procedure for ablation lesion assessment. Contiguity of LGE-CMR-detected ablation lesions will be compared with a matched control group of patients that have undergone PVI accomplished by ablation index-guided ablation with 40 W following the CLOSE protocol.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 128
- paroxysmal or early persistent (max. 3 months) atrial fibrillation
- scheduled for PVI-only catheter ablation
- long-standing persistent atrial fibrillation
- previous left atrial ablation
- claustrophobia preventing CMR
- sever renal insufficiency (GFR >30 ml/min)
- gadolinium contrast allergy
- presence of implantable devices not compatible with magnetic resonance
- pregnancy and lactation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ablation lesion contiguity as assessed by LGE-CMR LGE-CMR at 3 months post-ablation Proportion of the circumferential ablation line covered by LGE (%)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital Clinic, University of Barcelona
🇪🇸Barcelona, Catalonia, Spain