A Prospective Randomised Controlled Study on Effects of Dexmedetomidine Infusion on plasma glucose and lactate levels in patients undergoing cardiac surgery on cardiopulmonary bypass under general Anesthesia.
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To find out the effects of Dexmedetomidine infusion on plasma Glucose and lactate levels in patients undergoing cardiac surgery on cardiopulmonary bypass under general Anesthesia
研究概览
简要总结
The surgery related stress response is considered a key factor of intraoperative dysglycemia. Surgery enhances sympathetic stimulation and subsequently increases levels of stress hormones glycogen synthesis, such as catecholamines, cortisol glucagon and growth hormones. Intraoperative dexmedetomidine infusion blunts the stress response and are known to be prominent in general Anesthesia, thereby decreasing the production of stress hormones that are glucose lactate and cortisol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA STATUS 2 or 3, NYHA CLASS 2, ELECTIVE SURGERY(CARDIAC).
排除标准
- •Patients with diabetes, hypertension and congestive heart failure.
- •Patients/Parents/Legal Guardians unwillingness.
结局指标
主要结局
To find out the effects of Dexmedetomidine infusion on plasma Glucose and lactate levels in patients undergoing cardiac surgery on cardiopulmonary bypass under general Anesthesia
时间窗: 1.Immediately after intubation | 2.After completion of surgery | 3. At the time of extubation | 4.6 hours after extubation | 5.12 hours after extubation | 6. 24 hours after extubation
次要结局
- To determine serum cortisol levels, post operative sedation scores, post operative pain scores, haemodynamics variables.(1.Immediately after intubation)
研究者
DR ANGAD KUMAR SINGH
Rajendra Institute of Medical Sciences Ranchi