Pilot Study: Functional Imaging of Cerebellar Mutism Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Brain Mass
- Sponsor
- Memorial Sloan Kettering Cancer Center
- Enrollment
- 4
- Locations
- 1
- Primary Endpoint
- investigate the feasibility of performing preoperative fMRI
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this study is to better understand why some children with cancer have difficulty speaking after brain surgery. Difficulty speaking may be due to known complications to the language centers in the brain. These language centers may be located in slightly different places in different people. This study will study which areas may be damaged.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Subject and/or guardian is able to provide written informed consent prior to study registration
- •Age ≥3 years and ≤21 years
- •Newly diagnosed, untreated mass in posterior fossa, either benign or malignant
- •Is being evaluated for surgical resection of the mass
- •Able to perform clinical language testing in English
Exclusion Criteria
- •Claustrophobia
- •Any contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander).
- •Pregnant or nursing female
- •Does not speak English as a primary language (as determined by the P.I. or treating physician after discussion with a potential subject and his/her family)
- •Preexisting language or developmental disorder that would limit ability to cooperate with testing (as determined by the P.I. or treating physician after interviewing potential subject and his/her family; for example, a child may be excluded if he/she has confirmed or suspected autism spectrum disorder, dysarthria, dyslexia, lisp, hypotonia, or other age inappropriate speech development)
Outcomes
Primary Outcomes
investigate the feasibility of performing preoperative fMRI
Time Frame: 1 year
in young children at risk for developing CMS after posterior fossa brain tumor resection. Age appropriate language functional MRI tasks targeting the cerebellar language centers will be performed in children before surgery and correlated with formal neuropsychological and language testing. The fMRI will be repeated after surgery. If ≥5 of the 7 subjects successfully complete ≥60% of the functional imaging tests, we will determine the pilot study to be successful and then pursue further study.
Secondary Outcomes
- To investigate potential changes in Diffusion Tensor Imaging (DTI) and tractography(1 year)
- To investigate potential changes in DTI after posterior fossa surgery(1 year)