Anterior Quadratus Lumborum Block Versus Erector Spina Plane Block in Percutaneous Nephrolithotomy Surgery

Completed

• Conditions: Anesthesia; Analgesia; Erector Spina Plane Block; Patient Controlled Analgesia; Quadratus Lumborum Block
• Interventions: Other: Group Control; Procedure: Group QLB3; Procedure: Group ESPB

• Registration Number: NCT05822492
• Lead Sponsor: Ondokuz Mayıs University

Brief Summary

In this study, it was aimed to evaluate the effects of anterior quadratus lumborum block (QLB3) and Erector Spina Plane Block (ESPB) on postoperative acute pain scores and opioid consumption in the first 24 hours in Percutaneous Nephrolithotomy Surgery

Detailed Description

Percutaneous nephrolithotomy (PCNL) is commonly used to treat large kidney stones. Patients usually complain of severe pain and discomfort postoperatively. Postoperative pain prolongs hospital stay, delays wound healing, increases infection rates, and increases the incidence of drug side effects.

Regional anesthesia is part of multimodal analgesia in treating postoperative pain. Facial plane blocks are among these procedures. Erector spina plane block (ESPB) is a peri-paravertebral regional anesthesia technique applied for the first time to treat thoracic neuropathic pain. In the literature, the effectiveness of upper abdomen and renal operations in pain management has been demonstrated. Quadratus lumborum block (QLB) was first described as an alternative to the transversus abdominis plane block. This block can be performed with three methods under ultrasound guidance. An anterior QLB (QLB3) block was used in this study. In this block, the local anesthetic drug is applied between the quadratus lumborum muscle and the psoas muscle fascia and spreads along the thoracolumbar fascia. This block provides anesthesia and analgesia in the T7-L1 dermatome area. QLB3 block has been applied in pyeloplasty, cholecystectomy, lower abdominal surgeries, cesarean sections, radical nephrectomy, and hip joint surgeries and provided adequate postoperative analgesia.

This study aimed to evaluate the effects of QLB3 block and ESPB block on pain scores and opioid consumption in patients undergoing PCNL.

Patients will be divided into three groups.

Group QLB3:

Patients who applied the OLB3 block and IV morphine-patient-controlled analgesia (PCA) before PCNL surgery were included in this group.

Group ESPB:

Patients who applied ESPB block and IV morphine-PCA before PCNL surgery were included in this group.

Group Control In this group, patients only applied general anesthesia and IV morphine-PCA.

Study Timeline

• Study First Submitted: 2023-04-10
• Study First Submitted QC: 2023-04-10
• Study Start: 2023-04-20
• Study First Posted: 2023-04-20
• Primary Completion: 2023-09-20
• Study Completion: 2023-09-30
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-02
• Last Update Posted: 2023-12-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• 18-65 years
• American Society of Anesthesiology score I-III patients scheduled for unilateral PCNL in elective conditions
• Patients with BMI <35 kg/m2

Exclusion Criteria

• Pregnancy
• Conditions where regional anesthesia is contraindicated (coagulopathy, international normalized ratio abnormality, thrombocytopenia, infection at the injection site)
• History of hypersensitivity or allergy to local anesthetics
• Patients with psychiatric disorders
• Patients with musculoskeletal deformities
• Patients with alcohol-drug dependence
• Patients with cognitive dysfunction (patients incapable of evaluating the NRS score)
• Patients who did not give consent / did not want to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group Control	Group Control	Patients who did not use any block before PCNL surgery were included in this group.
Group QLB3	Group QLB3	Patients who applied the QLB3 block before PCNL surgery were included in this group.
Group ESPB	Group ESPB	Patients who applied ESP block before PCNL surgery were included in this group.

Primary Outcome Measures

Name	Time	Method
Morphine consumption in the first 24 hours after surgery	postoperative day 1	Morphine consumption in the first 24 hours after surgery will be measured. Patients will be able to request opioids via a PCA device when their NRS score is ≥ 4.

Secondary Outcome Measures

Name	Time	Method
Postoperative pain scores	postoperative day 1	Pain status at rest and while activity will be assessed by numeric rating scale (NRS) score at 0, 3, 6, 12, 18, and 24 hours after surgery. In addition, the time until the first analgesic requirement will be recorded. The NRS is an 11-point numeric scale that ranges from 0 to 10.
Intraoperative remifentanil consumption	The remifentanil consumption will be recorded from anesthesia induction until the patient is referred to the recovery unit, up to 150 minutes.	The total amount of remifentanil consumed will be recorded.
The number of patient required rescue analgesia	postoperative day 1	The number of patients requiring rescue analgesics will be recorded over 24 hours.
The mean arterial pressure	The mean arterial pressure was recorded preoperatively, one minute after the induction, and every 15-30 minutes until the patient was referred to the recovery unit, up to 180 minutes.	The mean arterial pressure was recorded preoperatively, one minute after the induction, and every 15-30 minutes until the patient was referred to the recovery unit.
The heart rate measurement	The heart rate was recorded preoperatively, one minute after the induction, and every 15-30 minutes until the patient was referred to the recovery unit, up to 180 minutes.	The heart rate was recorded preoperatively, one minute after the induction, and every 15-30 minutes until the patient was referred to the recovery unit.
The postoperative nausea and vomiting (PONV) scores and the number of patients requiring antiemetic medication.	postoperative day 1	The severity of postoperative nausea and vomiting (PONV) will be assessed using a descriptive verbal rating scale at 0, 3, 6, 12, 18, and 24 hours after extubation. If a score of 3 or more, ondansetron 4 mg IV will be administered and will repeat after 8 hours if required. The PONV scale is 0 = no nausea; 1 = slight nausea; 2 = moderate nausea; 3 = vomiting once; and 4 = vomiting more than once.
Time of first analgesic request	postoperative day 1	Time at which the first analgesic is requested
The number of patients with complications	Postoperative 7 days on an average	The number of patients has any complications -directly related to the block or the drug used in the block- will be recorded

Trial Locations

Locations (1)

Ondokuz mayıs Universty; 🇹🇷 Samsun, Turkey