To see the effectiveness of a drug (dexmedetomidine) given by two methods (in vein or nose) in decreasing the rise of pulse rate and blood pressure while giving anaesthesia.

Recruiting

• Conditions: Medical and Surgical, (2) ICD-10 Condition: O||Medical and Surgical,

• Registration Number: CTRI/2019/08/020584
• Lead Sponsor: VMMC and Safdarjung Hospital

Brief Summary

This study will help us to find out effective of intravenoyus versus nasal dexmedetomidine in blunting of hameodynamic response to intubation. It is important to blunt haemodynamic response to intubation as it can have deleterious effects in patents with cardiac disease or hypertension.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-15
• Last Update Posted: 2020-05-05

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1.Adult patients (18-65 years), of either sex, having ASA physical status I 2.Undergoing elective surgery under general anaesthesia with tracheal intubation.

Exclusion Criteria

1.Patients having any nasal pathology 2.Predicted difficult laryngoscopy/ intubation 3.Pregnancy 4.Known allergy to study medication.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the efficacy of intravenous with intranasal dexmedetomidine for attenuation of haemodynamic response to laryngoscopy and tracheal intubation with regard to heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure at various time points	Haemodynamic parameters heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure), oxygen saturation (SpO2) and end tidal carbon dioxide (EtCO2) will be recorded at 1.baseline | 2.after nasal pre-medication (at 10 and 20 min), | 3. 5 and 10 min of intravenous infusion of study drug/pre-induction, | 4.post-induction, | 5. 3 min post induction | 6. post-intubation (at 1,3,5 and 10 min)

Secondary Outcome Measures

Name	Time	Method
1. Pre-induction sedation score	2. Induction dose of propofol

Trial Locations

Locations (1)

Surgery OT ,Department of Anaesthesia ,Main OT Complex; 🇮🇳 South, DELHI, India

Surgery OT ,Department of Anaesthesia ,Main OT Complex

🇮🇳South, DELHI, India

DR Anjali Kochhar

Principal investigator

9999197721

kochharanjali0@gmail.com