Physiological and Psychiatric Effects From Aerobic High Intensity Endurance Training and Maximal Strength Training in Patients Suffering From Schizophrenia: A Controlled Clinical Trial.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- peak aerobic capacity (VO2peak)
研究概览
简要总结
This study investigates treatment effects from aerobic endurance training, maximal strength training and computer game on aerobic capacity, work efficiency and psychiatric symptoms in patients suffering from schizophrenia. The study is a controlled trial. The aim is to describe the population in respect to aerobic capacity and muscular strength. Low aerobic capacity and muscular strength are important risk factors for cardiovascular disease (CVD). The study also aim to evaluate physical and psychiatric effects from physical training. Effects from participation in physical training or computer game on symptoms, depression and quality of life will be investigated. Data will be collected between October 2005 and August 2007.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •schizophrenia, schizotypal and delusional disorders (F20-F29) according to the international statistical classification of diseases and related health problems, 10th revision (ICD-10) prepared by the World Health Organization. Patients must have stable antipsychotic medication for six weeks prior to participation.
排除标准
- •coronary artery disease, chronic obstructive pulmonary disease, not being able to perform physical treadmill testing and exercise, and less than 80% compliance to the training sessions. All subjects go through a physical health examination at inclusion.
研究组 & 干预措施
Aerobic interval training (AIT)
AIT is 4x4 minutes interval training on a treadmill at 85 to 95 % HRpeak interspersed with 3 min of active resting periods at a work load corresponding to 70 % HRpeak between each interval. Patients performed the intervals walking or running with a minimum of 5 % inclination.
干预措施: Aerobic high-intensity interval training (AIT) (Other)
Computer game training (CG)
36 minutes playing supervised computer games, Tetris, Xbox
干预措施: Computer game training (CG) (Other)
Maximal strength training (MST)
MST is performed in a leg press machine. The weight is lowered in a controlled manner in the eccentric phase until the patient reached 90 degrees in the knee joint. Then the patients has a short stop (~0.5 second) before the weight is moved as rapidly as possible to complete extension. The training volume is 4 sets of 4RM (i.e. 85-90 % 1RM). The training load is increased with 2.5-5 kg each time patients managed to perform 4 sets with the determined load or each training session.
干预措施: Maximal strength training (Other)
结局指标
主要结局
peak aerobic capacity (VO2peak)
时间窗: Pre- and Posttest
次要结局
- Fasting blood samples, systolic and diastolic blood pressure.(Pre- and posttest)
- Maximal strength, measured as one repetition maximum (1RM) in a incline leg press machine (Technogym)(Pre- and Post test)
- The 36-item short form (SF-36)(Pre- and Posttest)
- Positive and Negative Syndrome Scale (PANSS)(Pre- and Posttest)
- Calgary Depression Scale for Schizophrenia (CDSS)(Pre- and Posttest)
- 60 Watt walking efficiency, Net efficiency(Pre- and Posttest)