Role of Central Venous to Arterial Carbon Dioxide Gradient in Outcomes of Sepsis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 112
- 试验地点
- 1
- 主要终点
- Role of Central venous to arterial carbon dioxide gradient in predicting sepsis outcomes
研究概览
简要总结
Sepsis is a heterogeneous and complex syndrome, characterized by a dysregulated host response to infection which can be life-threatening.
• The major causes of admission to Intensive Care Units (ICUs)
• Mortality rate ranges from 25-50%.
• The association of lactate level with mortality in patients with suspected infection and sepsis is well established.
• ΔpCO2 reflects the difference in partial pressure of carbon dioxide (pCO2) between central venous blood and arterial blood.
• It has been proposed as an indicator of tissue perfusion and may offer insights into sepsis severity.
• While it is not a direct measure of oxygen delivery, ΔpCO2 can provide valuable information about the adequacy of tissue perfusion and the presence of global tissue hypoxia.
• This study aimed to determine the change in central venous and arterial pCO2 difference (ΔpCO2 ) at 0 and 6 hours to predict outcome in sepsis patients. This can act as an alternative marker to lactate clearance.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Age above 18years.
- •Diagnosis of sepsis with predefined criteria.
- •Admitted in ICU/ high dependency unit (HDU).
排除标准
- •Acute Exacerbation COPD.
- •Any chronic respiratory illness with pCO 2 more than 50mm Hg.
- •Liver dysfunction defined as encephalopathy and impaired synthetic function (international normalized ratio [INR] of ≥1.5) 22 , a patient with cirrhosis or pre-existing liver disease.
- •Pregnant female.
- •End stage malignancy cases or cases admitted with treatment related complications.
- •Do not resuscitate orders.
结局指标
主要结局
Role of Central venous to arterial carbon dioxide gradient in predicting sepsis outcomes
时间窗: Time at which patient gets discharged from the ICU or died in the ICU
次要结局
- Change in ΔpCO2 from 0 to 2 hours & association with sepsis outcomes.(Time at which patient gets discharged from the ICU or died in the ICU)
- Change in ΔpCO 2 from 0 to 6 hours & association with sepsis outcomes.
- Change in ΔpCO 2 & association with lactate clearance.
研究者
Samruddhi Chougale
Pandit B.D Sharma, PGIMS, Rohtak