Resistance to chemotherapy induced by plasma from healthy volunteers after fish oil consumptio
Completed
- Conditions
- het gaat hier om gezonde vrijwilligers zonder aandoening.chemoresistanceinsensitivity to chemotherapy
- Registration Number
- NL-OMON38363
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 28
Inclusion Criteria
1. The volunteer must be >= 18 years of age
2. The volunteer must be healthy, meaning:
* no history of diabetes mellitus
* no history of immune disorders
* no history of hypercholesterolemia
* no use of anti-coagulant medication
* no breast feeding
* no allergy to fish or related products
3. The patient may not have used fish oil products within 2 weeks before start of the study
4. The patient may not have eaten a fish meal within 1 week before the start of the study
5. The patient must have given written informed consent
Exclusion Criteria
Any other condition by which the volunteer does not meet the inclusion criteria.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary endpoint:<br /><br>To determine the level of 16:4(n-3) in plasma withdrawn from volunteers that<br /><br>have ingested fish oil or fish.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary endpoint:<br /><br>The ability of plasma withdrawn from volunteers that have ingested fish oil or<br /><br>fish to induce resistance in an in vitro tumor cell culture, or in vivo in<br /><br>mouse models.</p><br>