Prevalence of vulnerable plaque in type 2 Diabetes Mellitus and its predictive value for future ischemic strokes
Withdrawn
- Conditions
- atherosclerosisdiabetes1008220610003216
- Registration Number
- NL-OMON41735
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 1680
Inclusion Criteria
* Subjects enrolled in de maastricht studie
* Subjects who have atherosclerotic plaques * 2mm, demonstrated in the carotid artery during vascular ultrasound in de maastricht studie.
Exclusion Criteria
* Pregnancy.
* Standard contra-indications for MRI (ferromagnetic implants like pacemakers or other electronic implants, metallic eye fragments, vascular clips, claustrophobia, etc).
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Presence of a vulnerable carotid plaque with intraplaque haemorrhage on MRI (on<br /><br>the left and/or right-hand side) in asymptomatic individuals with type 2<br /><br>diabetes, impaired and normal glucose tolerance and a 2 mm plaque as identified<br /><br>by an ultrasound examination.<br /><br>Number of new ischemic stroke events after 10 years of follow-up. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Presence of brain infarct(s) on brain MRI.<br /><br>Number of cardiovascular events after 10 years of follow-up<br /><br>Subject characteristics (age, gender, cardiovascular risk factors, previous<br /><br>cardiovascular symptoms)<br /><br>Glucose tolerance tests </p><br>