Prefrontal mechanisms underlying the effects of positive and negative expectation on pain: temporal stability of behavioral and EEG effects
Not Applicable
- Conditions
- Pain and Pain Treatment
- Registration Number
- DRKS00026174
- Lead Sponsor
- niversitätsklinikum Hamburg-Eppendorf
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 41
Inclusion Criteria
Healthy adults with normal or corrected-to-normal vision, right-handed
Exclusion Criteria
- any contraindications for MRI measurement (metal implants, non-removable piercings, heart
pacemaker, tattoos close to the head, known claustrophobia)
- red-green deficiency
- chronic or acute disease or pain
- neurological or psychiatric disorders
- pregnancy
- regular medication intake (except contraceptive), recent use of psychotropic or analgesic substances
- use of illegal drugs
- consumption of caffeine 2 hours before MRI testing and consumption of alcohol on the day of testing
and the previous day
- smoking
- participation in any medication-associated experimental study in the last 6 months
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Our aim is to assess time-frequency (EEG)neural characteristics of positive and negative expectations on pain in the expectation phase prior to the application of painful stimuli and to explore the stability of placbeo and nocebo effects.
- Secondary Outcome Measures
Name Time Method In addition, we will examine the neural processes after the cue presentation and after the application of<br>the pain stimuli.