Consequences of prefrontal brain stimulation on impulsivity – a simultaneous tDCS-fMRI study
Not Applicable
Recruiting
- Conditions
- Healthy volunteers
- Registration Number
- DRKS00024471
- Lead Sponsor
- niversitätsklinikum der RWTH Aachen, Medizinische Fakultät
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 140
Inclusion Criteria
Smoker (>10 cigarettes a day),
Non-Smoker,
right-handed,
fluent in the german language
Exclusion Criteria
Inclusion Criteria are not fulfilled, Exclusion criteria for MRI research are positive, mental illness according to SKID 5, taking any form of illegal substances
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method *Confirmatory*<br><br>Difference in stop-signal reaction time before and after stimulation. Influence of HD-tDCS application, nicotine and trait impulsivity (BIS11).
- Secondary Outcome Measures
Name Time Method *Exploratory*<br><br>Difference of resting-state functional connectivity before-, during- and after HD-tDCS application between groups and in consideration of a potential improvement in response inhibition. <br><br>Influence of grey-matter volume of the inferior frontal gyrus on the effectivity of HD-tDCS on response inhibtion.<br><br>Simulation of the electric field that is induced by the HD-tDCS application (Using a T1 and a T2 weighted MRI measurement, the electric field that is created can be individually modelled for every participant.)<br><br>CO2 measurement of smokers.<br><br>SSRT: Reaction time, percent of correctly inhibited trials, percentage of errors (clicking the wrong button) <br><br>Different Questionnaires (UPPS, SKID, PANAS, Audit, RPQ, AQ, SPSRQ)<br><br>Neuropsychological tests (WST, TMT-A, TMT-B, digit span forward and backward)<br><br><br><br><br><br>