NCT01386229Unknown4 期
A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- A more than 15% change in mean arterial pressure and heart rate after anesthesia induction
研究概览
简要总结
The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents regarding their effect on adrenal gland steroid synthesis in these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for elective coronary artery bypass graft surgery with cardiopulmonary bypass
- •Patient's written informed consent for study participation
- •Ejection fraction ≥ 35%
排除标准
- •Allergy to study drugs
- •Redo surgery
研究组 & 干预措施
Ketamine
Active Comparator
干预措施: Ketamine (Drug)
Etomidate
Active Comparator
干预措施: Etomidate (Drug)
结局指标
主要结局
A more than 15% change in mean arterial pressure and heart rate after anesthesia induction
时间窗: For 60 minutes after anesthesia induction
次要结局
- Adrenal gland steroid synthesis suppression(24 hours and 5 days after study drug administration)
研究者
研究点 (1)
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