Casinomacropeptide and Satiety

Not Applicable

Completed

• Conditions: Lack of Satiety; Appetite Disorders; Excess Intake of Macronutrients
• Interventions: Other: Whey-CMP; Other: MPI; Other: Whey; Other: Control; Other: CMP; Other: CPI

• Registration Number: NCT01587911
• Lead Sponsor: University of California, Davis

Brief Summary

Assessing 5 different milk derived proteins versus placebo for appetite regulation and satiety, delivered via shake vehicle.

Detailed Description

Assessing 5 different milk derived proteins versus placebo for appetite regulation and satiety, delivered via shake vehicle. Subjects will attend a 5 hour post-prandial study day. Subjects will keep food records 1 and 3 days prior to study visit, day of visit, and day after visit; food to be weighed using study provided dietary scale.

Study Timeline

• Study Start: 2008-05
• Primary Completion: 2009-05
• Study First Submitted: 2012-04-26
• Study First Submitted QC: 2012-04-27
• Study First Posted: 2012-04-30
• Study Completion: 2015-09
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-10
• Last Update Posted: 2017-08-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

• Healthy
• Unrestrained (score ≤ 10 on the Eating Inventory (EI) questionnaire, Stunkard and Messick 1985)
• Women
• 18 years of age
• Consume a low/moderate protein diet (12-20% protein energy).
• Meet BMI criteria of 19 to 24 kg/m2 OR 29 to 34 kg/m2, inclusive.

Exclusion Criteria

• Women who score ≥ 10 on the Beck Depression Inventory (BDI, Beck and Beamesdorfer 1974)
• Women who score ≥ 30 on Eating Attitudes Test (EAT, Garner and Garfinkel 1979),
• Have current or past (previous 1 year) medical conditions that may interfere with any of the outcomes of this study.
• Weigh less than 110 lbs
• Are currently or have been modifying diet or exercise patterns to gain or lose weight in previous 60 days
• Have unstable body weight (fluctuations of ≥ 5 kg in 60 day period)
• Are excessive exercisers or trained athletes
• Taking any medications that would affect appetite or any other study-described endpoint will also be excluded.
• Allergies or intolerances to foods consumed in the study.
• Smoker
• Pregnant/lactation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Whey-CMP	Whey-CMP	Complete whey protein missing the CMP (aka GMP) portion of the peptide.
MPI	MPI	Complete milk protein.
Whey protein	Whey	Complete whey protein.
Control	Control	Placebo preload control, matched for energy.
CMP (casinomacropeptide)	CMP	Small peptide cleaved from complete whey protein.
CPI (casein)	CPI	Preload containing casein.

Primary Outcome Measures

Name	Time	Method
Post-prandial satiety	6 hours	Assessing biobehavioral aspects of appetite regulation through VAS.

Secondary Outcome Measures

Name	Time	Method
Extended satiety	48 hours	Utilizing self reported food intake, looking for changes associated with the different proetin compositions of the shakes.

Trial Locations

Locations (1)

University of California, Davis (Ragle Human Nutrition Research Center); 🇺🇸 Davis, California, United States