Dairy Proteins and Postprandial Appetite Regulation and Energy Expenditure

Not Applicable

Completed

• Conditions: Obesity
• Interventions: Dietary Supplement: dairy proteins

• Registration Number: NCT01133964
• Lead Sponsor: University of Copenhagen

Brief Summary

The aim of this study is to examine the effect of dairy proteins (whey and casein) on postprandial appetite regulation and energy expenditure.

Detailed Description

Several studies have shown that a high protein intake is associated with a increased loss of body weight and body fat as compared to a diet with a normal or low protein content. The effect seems to be due to a higher diet induced thermogenesis and increase satiety.

Milk has a high content of proteins. It contains two very different types of protein: whey and casein. Whey is a soluble protein whereas casein clots into the stomach, which delays its gastric emptying and thus probably results in a slower release of amino acids. It is therefore very likely that the two types of protein affect the thermogenesis and appetite regulation differently.

The aim of the present study is to examine the effect of dairy proteins (whey and casein) on postprandial energy expenditure, substrate oxidation and appetite regulation.

The study will have a cross-over design including four meals each including a test drink (milk, casein drink, whey drink or water).

Study Timeline

• Status Verified: 2008-09
• Study Start: 2008-10
• Primary Completion: 2009-12
• Study Completion: 2009-12
• Study First Submitted: 2010-05-27
• Study First Submitted QC: 2010-05-28
• Study First Posted: 2010-05-31
• Last Update Submitted: 2011-06-23
• Last Update Posted: 2011-06-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 22

Inclusion Criteria

• healthy males
• body mass index (BMI) 25-30 kg/m2
• 18-50 years
• weight stable

Exclusion Criteria

• smoker
• regular use of medicine
• elitist athletes
• participation in other intervention studies

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
milk	dairy proteins	skim milk
casein drink	dairy proteins	-
whey drink	dairy proteins	-
water	dairy proteins	-

Primary Outcome Measures

Name	Time	Method
Substrate oxidation	5 hours
Subjective appetite sensation	5 hours
Energy expenditure	5 hours

Trial Locations

Locations (1)

Department og Human Nutrition, Life, University of Copenhagen; 🇩🇰 Copenhagen, Denmark