Impact of Dairy Products on Postprandial Inflammation

Not Applicable

Completed

• Conditions: Obesity; Inflammation; Nutritional Intervention
• Interventions: Other: consumption of high fat test meal with dairy products; Other: consumption of high fat test meal without dairy products; Other: consumption of test meal based on dairy products

• Registration Number: NCT01885416
• Lead Sponsor: Agroscope Liebefeld-Posieux Research Station ALP

Brief Summary

The study will quantitatively evaluate the systemic, postprandial inflammatory and metabolic response to the ingestion of three different meals in obese subjects. The administered meals will differ in the proportion of dairy products. Postprandial response will be monitored during 6 hours after meal consumption.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01
• Study First Submitted: 2013-06-19
• Study First Submitted QC: 2013-06-20
• Study First Posted: 2013-06-25
• Primary Completion: 2013-09
• Status Verified: 2013-11
• Study Completion: 2013-11
• Last Update Submitted: 2013-11-18
• Last Update Posted: 2013-11-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 21

Inclusion Criteria

• male
• BMI ≥ 20 kg/m2
• age 25-55 y
• informed consent

Exclusion Criteria

• Physiological or psychological diseases
• Allergies to food or intolerance to high-fat meal
• Vegetarians
• Chronic intake of drugs
• Smokers
• Diabetes mellitus Type I and II
• Debilitating kidney diseases
• Debilitating liver diseases
• Clinically established coronary heart diseases
• Ingestion of vitamins or dietary supplements during the course of the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
high fat meal with additional milk	consumption of high fat test meal with dairy products	high fat meal with additional milk
high fat meal without dairy products	consumption of high fat test meal without dairy products	high fat meal without dairy products
dairy product meal	consumption of test meal based on dairy products	dairy product meal

Primary Outcome Measures

Name	Time	Method
Inflammation markers in blood plasma (IL-6, TNF-alpha)	0,6h

Secondary Outcome Measures

Name	Time	Method
Biomarkers in blood (serum insulin, plasma glucose, GLP-1, lipids)	0,1,2,4,6h
Endotoxin in blood serum	0,6h

Trial Locations

Locations (1)

University Hospital, Inselspital Berne; 🇨🇭 Bern, Switzerland