Liver Regeneration After Liver Resection

• Conditions: Hepatectomy; Liver Diseases
• Interventions: Procedure: Liver biopsy

• Registration Number: NCT01220986
• Lead Sponsor: Nottingham University Hospitals NHS Trust

Brief Summary

The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy. The investigators hypothesise that liver regeneration after right hepatectomy in humans is associated with Kupffer cell activation and initiation of the innate immune response and that impaired liver regeneration, liver failure and sepsis following liver resection are associated with Kupffer cell dysfunction and an impaired innate immune response. The objectives for this study are to characterise Kupffer cell activity and the innate immune response in human liver before and after right hepatectomy.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-08
• Status Verified: 2010-10
• Study First Submitted: 2010-10-13
• Study First Submitted QC: 2010-10-13
• Last Update Submitted: 2010-10-13
• Study First Posted: 2010-10-14
• Last Update Posted: 2010-10-14
• Primary Completion: 2011-12
• Study Completion: 2012-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients requiring right hepatectomy for colorectal liver metastases

Exclusion Criteria

• Age >75, neoadjuvant chemotherapy, recurrent disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Right hepatectomy	Liver biopsy	Intervals from inflow division.

Trial Locations

Locations (1)

Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus; 🇬🇧 Nottingham, Nottinghamshire, United Kingdom