Reactivation of Varicella Zoster Virus and Risk of Vascular Disease in the Health Survey for England: a Nested Case Control Study
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Odds ratio for the effect of high serum antibody titre on stroke or other vascular outcomes
研究概览
简要总结
The purpose of this study is to investigate whether there is an association between stroke or heart attack and reactivation of varicella zoster virus, measured by antibody levels, using linked data from the Health Survey for England and secondary care.
详细描述
This study will use a case control design to investigate whether adult participants in the Health Survey for England between 2009 and 2013 who were admitted to hospital with either a stroke or heart attack had higher preceding levels of varicella zoster virus antibodies measured in stored serum samples compared to matched controls with no history of heart attack or stroke, controlling for a range of potential demographic, lifestyle and clinical confounders.
This study is funded by the University College London Hospitals Biomedical Research Centre Fast Track grant scheme and has received ethics approval (ref 15/NW/0456).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Previous participant in the HSE between 2009 and 2013 with stored serum available.
- •Either a record of stroke or TIA or MI in linked HES data between 01/01/2009 and 31/12/2013 or selected as a matched control for those with a record of stroke/ TIA/MI in HES data.
- •Male or female, aged 16 years or above.
排除标准
- •HSE participant with no stored serum sample
结局指标
主要结局
Odds ratio for the effect of high serum antibody titre on stroke or other vascular outcomes
时间窗: Outcome assessed within 5 years of serum sample
次要结局
- Prevalence of age- and sex-specific serum VZV antibody titres as a marker for virus reactivation(Assessed at baseline recruitment to the HSE)