Effect of Ashvatha Phala Churna and Shveta Palandu Swarasa Bhavita Yavani in Ksheena Shukra(low sperm count)
- Conditions
- Patients suffering from oligozoospermia
- Registration Number
- CTRI/2015/07/006036
- Lead Sponsor
- IPGT And R A GAU Jamnagar
- Brief Summary
1. **To evaluate and compare the clinical efficacy of *Ashvatha Phala Churna* and *Palandu Swarasa Bhavita Yavani Vati* on *Ksheena Shukra* (Oligozoospermia).**
**Introduction**
Among eight type of *Shukra Dosha , Ksheena Shukra* is caused due to vitiation of *Vata*and *Pitta* and *Daurbalya, Klaibya, Shukra Avisarga, Pandu etc*. have been mentioned as its symptom. *Ksheena Shukra*, results due to *ShukravahaStrotodushti*, hence all factors which lead to *Shukravaha Strotodushti* play an important role in producing *Ksheena Shukra*. This include *Shukradushtikara Ahara* and *Vihara* like excessive intake of *Amla-lavana-katu-tikta-kashayaRasa, exposure to Vata-Atapa, Shrama, Bhaya, Shoka ,Krodha* etc, which canbe considered as the primary cause of *KsheenaShukra*. Intake of *Madhura* and *Tikta Rasa* food and proper *Shodhana* of the body at proper time arethe major treatment for *Ksheena Kshukra*.
**AIMS & OBJECTIVES:**
Toevaluate and compare the clinical efficacy of *Ashvatha Phala Churna* and *Shveta* *Palandu Swarasa Bhavita Yavani Vati* after performing *Virechana Karma*on *Ksheena Shukra* (Oligozoospermia).
The thesis entitled “**AComparative study of *AshvathaPhala Churna* and *Shveta Palandu Swarasa Bhavita Yavani* in the management of *Ksheena Shukra* w.s.r to Oligozoospermia**†comprises of four parts viz.Conceptualstudy, Clinical study, Discussion, Summary and conclusion.
The total study was divided into conceptual contriveand clinical contrive.
**Conceptual Contrive**
The conceptual study has beenpresented under the heading of Disease and Drug review. In disease review, the detailsof historical aspects of *Shukra* and *Kshina shukra* have been mentioned. Then concept of *Shukra*which explains etymology, synonyms, definition of *Shukra, Retas,* *Virya*;origin and production of *Shukra* (spermatogenesis), characters andfunctions of *Shukra* (semen) has been discussed. This is followed by *NidanaPanchaka* of *Kshinashukra* such as various kinds of *Nidana, Rupa,Samprapti* and *Chikitsa* of *Kshina shukra* along with *Pathyapathya*have been dealt in length.
For the further understandingof pathophysiology review of oligozoospermia has been presented.
In Drug review,pharmcognostical, pharmaceutical and other details of the drug under trial viz.*Ashvatha PhalaChurna* and *Shveta**Palandu Swarasa Bhavita Yavani Vati* along with method ofpreparation of both drugs are in detail.
Drug review of the drugs usedfor *Virechana Karma* has also beendiscussed.
**Clinical Contrive:**
In the second chapter entilledclinical study embodies the methodology, selection of patients and methodadopted for present clinical trial. It is followed by presentation of theresults obtained in the clinical trial carried out on 38 patients of *Kshinashukra* along with its statistical analysis. The data obtained in theclinical study have been analysed and discussed in the detail in the thirdchapter under the caption of Discussion.
For the clinical study, 40 male patients complainingof symptoms of *Ksheena Shukra* or suffering from primary or secondaryinfertility more than one year and having sperm count less than 15 million/mland willing to participate for the clinical trial were selected irrespective ofreligion, caste from the O.P.D ofKayachikitsa Department or referred from SRPT Department of I.P.G.T.& R.A.hospital, Jamnagar. Consentwas taken from all subjects before including in the present study.
The selected patients were randomly dividedinto the following two groups, and managed for duration of two month additionto the time taken for *Virechana Karma*.
Patientswere first subjected to *Virechana,* asper classics, for beginning 3 days 2gm of *Trikatu*powder with warm water was given thrice a day before meal. After achievingsymptoms of *Samyaka Deepana* and *Pachana Snehapana* was done with *Suddha* *Godhrita* for 3-7 days in increasing dose depending upon *Koshta* and *Agni* of patient till *Samyaka**Snehapana Lakshana* were achieved.This was followed by *Sarvanga Abhyanga*and *Swedana* for 3 days were patientwas kept on normal diet. On the 4th day, *Abhyanga* and *Swedana* inthe morning *Virechana Yoga* whichconsisited of *Kwatha( Triphala + Trivritta*)with *Danti Churna* was given. Average8 hour and 8 minute were taken by the patients for Virechana and maximumpatients (92.5%) reported Madhyama Shuddhi. After completion of Samsrjana Krama, there patients were randomly divided into two groups. After this patient ofgroup A were given *Ashwattha Phala Churna* 3 gm twice a day orally daily in morningand evening before meal with a cup of warm milk with *Sharkara*for the duration of 60th day,while in group B *Shveta Palandu Swarasa BhavitaYavani Vati* was given in the dose of 4 *Vati(500mg each )*twice a day orally morning and eveningbefore meal with *Anupana* of 5ml of *Godhrita for duration of*60th day.
Itis though that drugs which are administered after *Shodhana* provides better and quicker effect as *Shodhana* helps to enhance the bioavailability of drugs.
The observation found on thebasis of generated data have been presented in brief which are as below:
40 male patients were studied in this series outof which maximum patients belonged to 21-30 years age group (52.5%), were toHindu (92.5%);coming from urban area ( 67.5%), belonging lower middle class(47.5 %); with secondary level education (60%); factory laborers (27.5 %); and doingheavy physical work (67.5%). Maximum patients had *Vishamagni* (77.5%), *VataPittaja Prakriti* (52.5%), habit of *Vishamashana* (87.5%) and taking *Lavana Rasa* dominant diet (60%). All thepatients (100%) of this study were found with well developed secondary sexual characterand having good relationship with their partner.
Maximum patients were found tobe habituated to Tobacco (52.5%) and most of the patients wearing cottonundergarments (97.5 %), but tight underwear (67.5 %), and taking habit of warmwater bath (67.5 %). Maximum number of patient complaint of disturbed sleep(62.5%) and 52.5 % of the patient had irregular bowel habit. Stress and worry(37.5%) was also reported in the patients.
Maximum number of patients were having Primaryinfertility (90%) with Moderate oligozoospermic conditions (52.5%) with 1-3 years of chronicity (37.5%)Associated symptoms of *Kshina Shukra* reported by the patients were *ShramaMaithuna* (80%), *Alpa Cheshta* (75%),*Daurbalya* (67.5%), *Alpa Shukra Pravritti* (57.5%), *MukhaSosha (*20%), *Sadana (*15%)*,* and Bhrama (75%).
Analysis of generated data tofind the effect of therapies on oligozoospermia showed that in Group A ( *Ashwattha Phala Churna*) 38patients were treated with *Ashvatha PhalaChurna* 3gm twice a day with warm milk and *Sharkara* for 60 days after performing of *Virechana Karma* provided increase in Sperm count of 59.78 %, 16.18% decrease in Abnormal forms, and increase in Semen volume by 36.81%.
In Group B (*Shveta**Palandu Swarasa Bhavita Yavani Vati* ); 38 patients were treated with 4 Vati twice a day withGoghrita for 60 days. Provided increase in sperm count (65%), and abnormal form of sperm (20.74%).
On assessing the effect oftherapies on associated symptoms it was found that
Ashvatha Phala Churna and *Shveta**Palandu Swarasa Bhavita Yavani Vati* administeredafter Virechana Karma provided statistically highly significant improvement (p<0.0001) in *Daurbalya,Sandhi Shula,Shrama, Maithune Ashakti,AlpaShukra Pravriti,* as well as subjective criteria i.e. sexualdesire, erectile function , erectile rigidity, ejaculatory function, orgasm,overall satisfaction, frequency of coitus, duration of coitus.
In additionin group B (*Shveta**Palandu Swarasa Bhavita Yavani Vati)* provided 24.08% increase inthe S.LH. In this group one patient was able to conceive his partner in thesecond month of treatment.
Overall effect oftherapies which was assessed on the basis of changes in semen parameters aswell as on subjective parameters. In Group A, (*Ashvatha Phala Churna*) given after *Virechana Karma*, 20% patients reported moderate improvement, 60%showed mild improvement and 20% patients remained unchanged. Whereas in *Shveta* *Palandu Swarasa BhavitaYavani Vati* group 10% patients showed moderate improvement, 70 %showed mild improvement and remaining 20% were remained unchanged.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 40
1 Sperm count less than 15 million per ml according to WHO 2010 2 Patient with clinical presentation of Ksheenashukra Oligozoospermia i e Daurbalya Klaibya Shukra Avisarga Pandu etc 3 Patient Yogya for Virechana.
1 Age below 20 and above 50 years 2 Sperm count more than 15 million per ml 3 Patient of azoospermia and aspermia 4 Patients of various diseases like varicocele accessory sex gland infection sexually transmitted diseases severe systemic diseases etc 5 Genetic disorders like Klinfelters syndrome 6 Taking treatment for major psychiatric problem 7 History of previous medications and trauma leading to oligozoospermia 8 Patient Ayogya for virechana.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The efficacy of the treatment will be assessed on the basis of improvement in the sperm count as well as subjective and objective criteria 60 days
- Secondary Outcome Measures
Name Time Method achieving of fertility 60 days
Trial Locations
- Locations (1)
Institute for Post Graduate Training and Research in Ayurved
🇮🇳Jamnagar, GUJARAT, India
Institute for Post Graduate Training and Research in Ayurved🇮🇳Jamnagar, GUJARAT, IndiaVarsakiya Jitendrakumar NathabhaiPrincipal investigator9879158817jeet12989@gmail.com