REgiStry in Chinese yoUng pEople With Sudden Cardiac Death（RESCUE-SCD）
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 450
- 试验地点
- 1
- 主要终点
- number of participants with cardiovascular deaths
研究概览
简要总结
The number of sudden cardiac death is up to 540,000 every year in China. Inherited cardiovascular disease is a common cause of sudden cardiac death in young people, and diseases often have the characteristics of family aggregation, so it has a huge psychological and economic burden on family members. Studying the etiology of sudden cardiac death from the molecular level under the model of precision medicine is helpful for screening patients and their relatives so as to further diagnosis, treatment and management, which has important clinical and social significance.
详细描述
In this study, sudden cardiac death and high risk of sudden cardiac death in patients younger than 40 years of age are recruited prospectively after informed consent was given. The investigator will collect the baseline clinical characteristics of the patients at enrollment, including comprehensive physical examination, laboratory testing of blood and urine, electrocardiography, 24-hour Holter, echocardiography, MRI and other examinations if necessary. The specimens retained include blood or oral swabs for all patients, and myocardium for patients receiving autopsy. Genetic testing will be performed to identify carried disease genes, genetic risk factors and potential therapy targets.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with sudden cardiac death and sudden unexplained death diagnosed according current practice guidelines.
- •Patients at high risk for sudden cardiac death. (1) Family history of sudden cardiac death at a young age; （2）Successful resuscitation from cardiac arrest; （3) Implantable cardioverter defibrillator implantation after a comprehensive clinical assessment of high risk of sudden cardiac death.
排除标准
- •Patients who refuse to sign the informed consent or decline follow-up.
- •Patients with sudden death due to car accidents, electric shocks, drowning, fighting, carbon monoxide poisoning and other external causes.
- •Patients with sudden death due to other definite causes, such as cerebrovascular accident, severe kidney disease, respiratory disease, neurological disease, etc.
结局指标
主要结局
number of participants with cardiovascular deaths
时间窗: an average of 2 years
including sudden cardiac death and deaths due to heart failure and stroke
次要结局
- number of participants with stroke(an average of 2 years)
- number of participants with heart failure(an average of 2 years)
- number of participants with myocardial infarction(an average of 2 years)
研究者
Lei.Song,MD.&ph.D
Principal Investigator, Clinical Professor
China National Center for Cardiovascular Diseases