Effect of a drug on blood pressure and heart rate on placement of a tube in trachea and dose requirement of propofol during induction of anaesthesia
Phase 1
Completed
- Conditions
- Health Condition 1: null- Patients belonging to the American Society of Anesthesiologists (ASA) physical status Grade I and II, age 15- 45 years of either gender and surgery requiring general anaesthesia
- Registration Number
- CTRI/2018/03/012416
- Lead Sponsor
- King Georges Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Patients belonging to the American Society of Anesthesiologists (ASA) physical status Grade I and II.
Age 15- 45 years of either gender.
Surgery requiring general anaesthesia for duration longer than 30 min
Exclusion Criteria
Patients with history of diabetes, hypertension, psychiatric illness, intake of antipsychotics, sedatives, anxiolytics and antiepileptic drugs, sleep disorders, obesity and drug allergy.
Patients with anticipated difficult intubation and those requiring more than one attempt or more than 20 s for laryngoscopy will be excluded from the study.
The pregnant and lactating females will also be excluded from the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Premedication with 6 mg melatonin administered orally 120 min before induction of anaesthesia is effective for providing haemodynamic stability at the time of laryngoscopy and intubation during induction of general anaethesia. <br/ ><br>Melatonin reduces the dose of propofol required for induction of anaesthesia. <br/ ><br>Timepoint: ONE YEAR
- Secondary Outcome Measures
Name Time Method Melatonin reduces the dose of propofol required for induction of anaesthesia. <br/ ><br>Timepoint: ONE YEAR