The PEACE (Posthumous Evaluation of Advanced Cancer Environment) Study

Recruiting

• Conditions: Solid Tumor, Adult; Cancer

• Registration Number: NCT03004755
• Lead Sponsor: University College, London

Brief Summary

Historically, cancer research has been limited by sample acquisition in late stage disease, often restricted to single sites of disease with limited parallel clinical data collection in terms of prior therapy exposure. The PEACE study is intended to facilitate tissue donation from multiple tumour sites in the post-mortem setting and enable future research using samples collected at post-mortem within different disciplines related to cancer research.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03
• Study First Submitted: 2016-12-21
• Study First Submitted QC: 2016-12-23
• Study First Posted: 2016-12-29
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-09
• Last Update Posted: 2024-05-10
• Primary Completion: 2024-09
• Study Completion: 2024-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Age 18 years or older
• Confirmed diagnosis of any form of solid malignancy with metastatic disease (where the site of origin is known or unknown), with the exception of primary brain tumour in which there may not be evidence of metastatic disease
• Oral and written informed consent from patient to enter the study and to undergo tumour harvesting after death or informed consent from a person in a qualifying relationship after the patient has died.

Exclusion Criteria

• Medical or psychiatric condition that would preclude informed consent
• History of intravenous drug abuse within the last 5 years
• History of known high-risk infections (e.g. HIV/AIDS-positive, hepatitis B/C, tuberculosis and Creutzfeldt-Jacob disease).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Perform 500 post mortems	5 years

Trial Locations

Locations (9)

Cambridge University NHS Trust; 🇬🇧 Cambridge, United Kingdom

University Hospitals of Leicester NHS Trust; 🇬🇧 Leicester, United Kingdom

Greater Glasgow Health Board; 🇬🇧 Glasgow, United Kingdom

Heart of England NHS Foundation Trust; 🇬🇧 Birmingham, United Kingdom

The Christie NHS Foundation Trust; 🇬🇧 Manchester, United Kingdom

The Royal Marsden NHS Foundation Trust; 🇬🇧 London, United Kingdom

Guy's and St Thomas NHS Foundation Trust; 🇬🇧 London, United Kingdom

Oxford University Hospitals NHS Trust; 🇬🇧 Oxford, United Kingdom

University College London Hospitals NHS Foundation Trust; 🇬🇧 London, United Kingdom