Effect of a Single Dose of Monosodium Glutamate on Delayed Gastric Emptying in Children
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 主要终点
- Reduced gastric emptying time
研究概览
简要总结
Children with a radionuclide gastric emptying test with abnormal results will undergo a second test with the addition of a weight adjusted dose of monosodium glutamate. The purpose of the study is to determine if a single dose of monosodium glutamate can shorten the gastric emptying time.
详细描述
There is evidence that monosodium glutamate has effects on synapsis at the gastric and duodenum level that results in stimulation of contractility resulting on increase rate of gastric emptying. The purpose of the study is to demonstrate that the administration of a single dose of monosodium glutamate can shorten the gastric emptying time.
Patients with a prior study indicating a delay of gastric empting time, will undergo a second test with the addition of a weight adjusted dose of monosodium glutamate. Each patient will serve as her/his own control. Results will be analysed by pair-T test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 12 Months 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •children with delayed gastric emptying not receiving prokinetic medication in the last 72 hours
排除标准
- •Prior gastrointestinal surgery, patients with known history of reaction to monosodium glutamate. History of neoplasia, autoimmune or inflammatory bowel disease.
研究组 & 干预措施
With monosodium glutamate
Results of one time gastric emptying study with a single dose of monosodium glutamate; 1 g for weight greater than 45 kg, 700mg between 35 and 44,900 kg, 600mg between 25 and 34,900, 500mg between 15 and 25 kg and 250mg in less than 15 kg
干预措施: Monosodium glutamate (Dietary Supplement)
结局指标
主要结局
Reduced gastric emptying time
时间窗: During the test (4 hours from intake)
Percentage of reduction of gastric emptying time when glutamate is administered compared to baseline
次要结局
未报告次要终点
研究者
Veronica Beatriz Busoni
Head of the Pediatric Gastroenterology and Hepatology Service
Hospital Italiano de Buenos Aires