Minocycline effects in patients with traumatic brain injury

Not Applicable

• Conditions: Head injury.; Cerebral contusion, laceration. traumatic intracerebral haemorrhage, Epidural haemorrhage, Extradural haemorrhage (traumatic), Traumatic subdural haemorrhage; S06.3 ,S06

• Registration Number: IRCT201602063014N12
• Lead Sponsor: Vice chancellor for research, Mazandaran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

The patients who have surgery within 12 hours after admission? glasgow coma scale less than or equal to 12
Exclusion criteria:
Pregnant women and lactating? hypersensitivity to tetracycline and minocycline medicine? history of systemic lupus erythematosus? incidence of pseudomembranous colitis

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
S100B protein. Timepoint: Day 1 (before intervention) , Days 2, 3, 4 (after intervention). Method of measurement: Spectrophotometry kit.;Neuron Specific Enolase (NSE). Timepoint: Day 1 (before intervention), Days 3, 5 (after intervention). Method of measurement: Spectrophotometry kit.

Secondary Outcome Measures

Name	Time	Method
ength of stay in ICU. Timepoint: Hospitalization period in ICU. Method of measurement: Calculating the number of days.;Glasgow coma scale changes. Timepoint: Hospitalization period in ICU. Method of measurement: GCS quiz.