NCT05724992招募中不适用
Standardised Genetic Profiling of Subjects Belonging to the Italian Multicenter Registry of Prospective Surveillance of Subjects at Genetic Risk of Pancreatic Cancer
Associazione Italiana per lo Studio del Pancreas2 个研究点 分布在 1 个国家目标入组 3,000 人开始时间: 2022年12月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 3,000
- 试验地点
- 2
- 主要终点
- Presence - absence of predisposing mutations
研究概览
简要总结
The goal of the PROPH-ITA Study is to perform genetic testing in family members of pancreatic cancer patients who may have a genetic predisposition. The subjects belong to the Italian Registry of Families At Risk of Pancreatic Cancer (IRFARPC, #NCT04095195). This investigational study will assess the genetic background of subjects with familiarity with pancreatic cancer only.
Participants may accept to undergo genetic testing as part of the IRFARPC registry, through a saliva-swab-based 41-gene panel test.
Up to 3,000 participants will be enrolled in this study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Being enrolled on the IRFARPC registry
- •Having familiarity for pancreatic cancer (according to the IRFARPC criteria, Capurso et al. Dig Liv Dis, 2020)
- •Willingness to participate in saliva-swab-based genetic testing
排除标准
- •Already known genetic mutation
结局指标
主要结局
Presence - absence of predisposing mutations
时间窗: 5 years
Prevalence of genetic mutations over the total tested
次要结局
- Correlation of genetic mutations with familial oncological history(5 years)
- Correlation of genetic mutations with personal oncological history(5 years)
研究者
研究点 (2)
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