Comparison of two different doses of dexmedetomidine as an adjuvant to levo-bupivacaine in ultrasound guided adductor canal block for postoperative analgesia in total knee replacement-A Prospective randomized double blinded Study
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
研究概览
简要总结
This prospective randomized double blinded study aims to compare two different doses of dexmedetomidine 0.5 microgram per kilogram and 1 microgram per kilogram as an adjuvant to 0.25 percent levobupivacaine in ultrasound guided adductor canal block for postoperative analgesia in patients undergoing total knee replacement under spinal anesthesia .Fifty ASA one and two patients will be randomized into two groups. The primary outcome is duration of postoperative analgesia. Secondary outcomes include visual analogue scale scores ,total rescue analgesic consumption, sedation levels and hemodynamic adverse effects. The study seeks to identify the optimal dexmedetomidine dose that provides superior analgesia with minimal side effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients undergoing elective TKR Patient’s belonging to American society of Anaesthesiologist class 1 and 2.
排除标准
- •Patient who does not give consent for the study Patient with any active infection at the site of administration of block Emergency surgeries Patients with local anesthetic allergy Presence of any pre-existing neuropathies Anticoagulation or bleeding disorders Patient with beta blockers Patient with cardiac diseases.
研究者
Dr Kanagalla Mary Shalini
Nizams Institute of medical sciences