Effects of calcium channel blockers on glucose tolerance and endothelial function in non-diabetic patients with essential hypertension: a comparative study between Azelnidipine and amlodipine on Glucose tolerance and Endothelial functioN - a crossover Trial (AGENT)
Not Applicable
- Conditions
- Hypertension
- Registration Number
- JPRN-UMIN000005837
- Lead Sponsor
- Juntendo University School of Medicine, Department of Cardiovascular Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 18
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients with history of allergy for the study drugs 2. Patients with history of cardiovascular disorders within 3 months 3. Patients with diabetes 4. Patients with serum creatinine >= 2.0mg/dl 5. Patients with systemic diseases 6. Patients with history of gastrointestinal surgery 7. Patients who are judged inappropriate for entry into this study by the investigator
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Blood pressure and heart rate 2. 75g OGTT 3. Endothelial function
- Secondary Outcome Measures
Name Time Method oxidative stress marker, inflammatory marker, circulating number of progenitor cells