Transfusion Requirements in Surgical Oncologic Patient
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Red Blood Cells Transfusion
- Sponsor
- University of Sao Paulo
- Enrollment
- 198
- Locations
- 1
- Primary Endpoint
- Composite end-point of mortality and severe complication
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
Blood transfusion during perioperative period in patients undergoing to major surgery has been associated to several postoperative complications. Particularly in oncologic surgery, red blood cell transfusion has been investigated as a factor of worse outcome and cancer recurrence due to postoperative impairment of cellular immunity. Although red blood cell transfusion has decreased in worldwide clinical practice, this issue still remains a matter of controversy in oncologic surgery. There are no prospective studies comparing outcomes between restrictive or liberal of blood transfusion strategy in oncologic surgery. This study is a prospective and randomized study comparing clinical outcomes between two strategies of transfusion in oncologic surgery - liberal or restrictive
Investigators
Juliano P Almeida, MD, Principal Investigator
Principal Investigator
University of Sao Paulo
Eligibility Criteria
Inclusion Criteria
- •Patients with cancer after major abdominal surgery requiring post-operative ICU admission
- •Adults patients
Exclusion Criteria
- •Age less than 18 year
- •Hematologic Malignances
- •Intensive care unit permanence lower than 24 hours
- •Renal Chronic Failure in Renal Replacement Therapy
- •Karnofsky Status \< 50
- •Previous anemia (hemoglobin lower than 9 g/dL)
- •Previous thrombocytopenia (platelet number lower than 50.000/mm3)
- •Previous known coagulopathy
- •Anticoagulation therapy
- •Those unable to receive blood transfusion
Outcomes
Primary Outcomes
Composite end-point of mortality and severe complication
Time Frame: 30 days
• The primary purpose of this study is to compare clinical outcomes after oncologic surgery in patients submitted to different strategies of red blood cell transfusion
Secondary Outcomes
- Hospital Length of Stay(60 days)