Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings for the Diagnosis of Either Acute Kidney Injury or Chronic Kidney Disease in Routine Practices
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Histopathological analysis of elementary lesions in nephropathology with dynamic full-field optical coherence tomography
Study Overview
Brief Summary
Kidney biopsy play a key role for the investigation of either acute kidney injury or chronic kidney disease. Despite possible complications due to the invasive nature of the biopsy, such procedure is still essential in a number of clinical situations to improve the diagnosis specificity of kidney disease, better inform about its prognosis and guide the management of a future treatment. Pursuing the idea to improve both performance and rapidity associated with the histopathological analysis of kidney biopsy, with a possible recourse to artificial intelligence-based renal pathology, the present study intends to assess the impact of direct histopathological examination of kidney biopsy with dynamic full-field optical coherence tomography in routine practices for the diagnosis of either acute kidney injury or chronic kidney disease.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients > 18 years of age with suspected acute kidney injury requiring biopsy in the nephrology department
- •patients > 18 years of age with suspected chronic kidney disease requiring biopsy in the nephrology department
Exclusion Criteria
- •inability to perform dynamic full-field optical coherence tomography observation at the moment of kidney biopsy
Arms & Interventions
NEPHROCT cohort
Patients > 18 years of age with suspected acute kidney injury or chronic kidney disease requiring biopsy in the nephrology department
Intervention: Dynamic full-field optical coherence tomography analysis of kidney biopsy (Other)
Outcomes
Primary Outcomes
Histopathological analysis of elementary lesions in nephropathology with dynamic full-field optical coherence tomography
Time Frame: Outcome measure is assessed 15 days following kidney biopsy
Provide a better understanding of the ability of dynamic full-field optical coherence tomography to identify and characterize common glomerular (abnormal / double contour of the glomerular basement membrane, focal segmental glomerulosclerosis, collapse of the glomerular tuft, proliferation of glomerular epithelial cells, endocapillary proliferation, mesangial expansion, necrosis and proliferation with mild increase in extracapillary cells...), vascular (hyaline change, fibrinoid change / necrosis, thrombosis, inflammation or necrosis of vascular walls, arteriosclerosis) and tubulointerstitial (acute tubular necrosis, cytoplasmic vacuolization, lipid inclusions in proximal / distal tubular cells, atrophy of tubules, edema, inflammation or interstitial fibrosis, cortical necrosis) lesions seen in kidney biopsy
Secondary Outcomes
- Histopathological analysis of healthy kidney biopsy with dynamic full-field optical coherence tomography(Outcome measure is assessed 15 days following kidney biopsy)
Investigators
Thomas Maldiney
Principal Investigator
Centre Hospitalier William Morey - Chalon sur Saône