Influence of Breakfast Consumption on Chlorogenic Acid Metabolism in Humans

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Soluble Coffee

• Registration Number: NCT01523028
• Lead Sponsor: Société des Produits Nestlé (SPN)

Brief Summary

Data and knowledge gathered on bioavailability of coffee phenolics is becoming more and more important, hence underlying the importance of better understanding the fate of these potential health promoting antioxidants. However, some analytical barriers as well as some key aspects of metabolism still remain to be fully elucidated to get the full picture of coffee metabolism and bioavailability. One aspect addressed in the present study is the impact of food matrix in modulating absorption, plasma appearance and urinary excretion of coffee bioactives.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-09
• Study First Submitted: 2012-01-27
• Study First Submitted QC: 2012-01-27
• Study First Posted: 2012-02-01
• Primary Completion: 2012-12
• Study Completion: 2012-12
• Status Verified: 2013-06
• Last Update Submitted: 2013-06-04
• Last Update Posted: 2013-06-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Healthy men and women
• Aged 20-44 years
• Caucasian origin
• Body mass index (BMI) 19-25 kg/m2
• Used to drinking coffee (similar to study coffee) on a daily basis
• Being able to tolerate a 48-hour coffee abstinence
• Normal oral glucose tolerance test
• Having signed the informed consent form

Exclusion Criteria

• Taking medication or dietary supplements
• Smoking
• Performing a competitive sport
• Having metabolic disorders
• Long gut transit time (>24 h)
• Blood donor
• Irregularity in menstrual cycle (for women)
• Pregnancy (for women)
• Subject who cannot be expected to comply with the study procedures.
• Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Coffee, bread and honey	Soluble Coffee	200 mL coffee + 2 bread rolls + honey
Coffee, bread and peanut butter	Soluble Coffee	200 mL coffee + 1 bread roll + peanut butter
200 mL black coffee	Soluble Coffee	-

Primary Outcome Measures

Name	Time	Method
Sum of plasma areas under the curve of coffee phenolics	Measurements over 24h after coffee ingestion

Secondary Outcome Measures

Name	Time	Method
Plasma AUC, Cmax and Tmax of individually measured coffee chlorogenic and phenolic acids	Measurements done over 24h after coffee ingestion
Urinary excretion of coffee chlorogenic and phenolic acids expressed as % ingested dose	Measurements done over 24h after coffee ingestion

Trial Locations

Locations (1)

University of Kaiserslautern; 🇩🇪 Kaiserslautern, Germany